Sjögren-Larsson Syndrome (SLS) is a genetic condition

SLS is caused by alterations in the gene for an enzyme that breaks down certain fats.

Patients with SLS cannot properly break down molecules called fatty aldehydes, which are toxic to the body and lead to the symptoms of the disease. 

symptoms of SLS

Common symptoms of SLS include:

  • dry, thickened, and scaling skin. (ichthyosis);
  • spastic movement in the legs, and,
  • cognitive impairment. 

Patients are usually born with some evidence of ichthyosis, and begin to show developmental delays in
the first few years of life.


Sjögren-Larsson Syndrome may also be referred to as Fatty Aldehyde Dehydrogenase (FALDH) Deficiency.

Sometimes Sjögren-Larsson Syndrome is confused with Sjögren's Syndrome, which is an immune system disorder. Sjögren-Larsson Syndrome is a different disease.

Living with or caring for someone with SLS can be challenging, but you are not alone. 

Click below to watch a video about someone living with SLS.

If you or someone you care for has been diagnosed with SLS, please register to be the first to know about treatments in development and the opportunity to participate in clinical trials.